I use Sulky KK2000, supposed to be environmentally safe and doesn't smell bad. It also works well. Just got 2 cans on sale at Overstock.com. Have also used 505 and that works well too. When I machine applique I do use a glue stick, but try to stay away from the edge where I will sew. In addition, I have used a think line of Elmers school glue when doing mitered borders, then heat set it works great!