Some people quilt without a hoop or a frame, and enjoy hand quilting that way.
I use a small hoop - it gives me flexibility and control. I've tried a large hoop on a stand but I found that I got a sore arm and shoulder after quilting for long periods.
Frames aren't for me, as I haven't worked out how to quilt in multiple directions.
So far I haven't sprayed any quilt - so I can't comment on that for you.
Do what works for you, and what feels right for your body.