Gosh, an interesting subject. Well, I would not have worked so darn hard. I'm a chemical engineer by profession and I always worked in a male dominated field. Very difficult at times. I worked ALL the time and saved every penny. Never took a vacation. But stress took it's toll on my health.
I have a good life, but if I had to do it over again...hmmmmmm...I'd at least take time for me. Not work 80-100 hour weeks. Now, I can sit back and do the things I always used to enjoy...knitting, quilting, cooking, reading (obviously, I don't work anymore!).