Most polycotton blends should be ok to work with. Down the road, there may be some pilling in the fabric, but if it is not washed often, it really shouldn't be much of an issue. If parts seem threadbare or thin, use a light iron-on interfacing behind them. The higher the % of poly, the more likely it will be to ravel or pull out, so you may want to tighten up your stitches a little, too.
It will be a lot harder to hand quilt than cotton. Are you machine quilting? All those buttons can be recycled, too.