Did he take you off it all at once? Mine wants me to go off Premarin which I have been taking since 1981. He cut my dosage in half, I did fine with that for three months. Now he wants me to go to one every other day, then after a few weeks to one every two days, etc. til I'm down to none. So far I haven't had any adverse reactions. He did say not to try to just stop all at once.