I don't know about he endo, but I do know that when I was going through menopause, I found that the extra strength New Phase, over the counter at Wal Mart help make the side effects less intense. At least I could sleep without waking up soaking wet! I would check with the doc first of course. It took about 3 weeks to kick in, but it helped. I ran out once and since money was tight decided to try it with out, cause did it really do anything? Well it took about 3 days, and then the misery began. Next payday, I got the New Phase again, and after about a week it, I was back to normal again.