I use Hobbs 80/20 and love it. When I first started quilting I used polyester but I hand-quilt and much prefer cotton batting. But that's b/c I like the look better ( I love antique quilts)
Also poly batting tends to pill through the quilt and I don't like that at all! I used to use Fairfield.
Live and learn- my first hand-quilted quilt was a very old quilt top and I used polyester batting. Never again :D