Melody- Don't get rid of the big old school desk next to the window.
Worse thing I did when we moved here was to get rid of a big old oak school desk we had. What a mistake.
Maybe, once you take everything out of the room and then re-organize, you will see your room in different 'light'. Gather al of your sewing/quilting stuff and organize it into piles-tools, fabrics, trims, threads, etc. Then you can get a better picture of what needs to go where.
Enjoy your family weekend.