All the time. I always take my sewing machine and a ton of fabric when we go in the RV. OK, so last year we went to Las Vegas and stayed in an RV park there, and I thought I would not take my sewing machine this one time. We were going for a friends wedding who was getting married at the Hilton. We stayed for 4 days and have been to casinos enough that they are not that interesting anymore and spent most of the time in the RV or walking the dogs. I just about went crazy without my sewing machine. Never again. I would rather have it with me and not use it than to leave it home and want it with me.
We have been traveling in first a 36' and now a 40' RV for 5 years now off and on. Love it and you will, too. You can take anything with you and don't have to pack and unpack. But, do plan on taking a tow so you can run around to quilt stores wherever you stay. We live in CA and made a 6000 mile round trip to South Carolina so got the real hang of doing this so if you have questions, just PM me. Love to talk RV'g abd quilting.