Basting it the old fashioned way is not bad either. If you do your work late at nite, you wouldn't want to spray in the house because of the fumes anyway. Quilting it in sections sounds like it'll be the easiest way to go. Especially because of the weight. I have not done it that way ye, but wish I had thought of it before I pieced this top together. I had to resort to handquilting the part of the top, it was too big to manuver around the small pieces on the machine.
Good LUck! CAn't wait to see it completed.