if you are doing quilt as you go, i would probably not use the spray...you are going to have too much overspray.
Instead, starch and press what you have just stitched down, and pin in place (i like flat head pins). Then put your next piece on RST and stitch. once it is stitched, press open again. The only part of qayg that I may consider using 505 is to attach backing squares to batting squares if that is the process you are using. it all depends upon the technique involved. do you know what I mean?