I have RLS and take horsechestnut for it. I buy mine at WalMart under the name of Venastat. Works great for me, but I am not on any prescription meds. If he isn't you might want to give it a try. RLS symptoms though are just a restless feeling in your legs that you feel you need to move them. He may have a B vitamin deficiency, that can lead to depression, etc. I ran out of mine once and fell into a miserable depression, cleared up in a matter of hours after getting back on my vitamins. He can go to a good health food store and get "muscle tested" for supplements he might need.