You'll be near Charleston. At the Market there, the old basket weavers and quilting women would sit and chat and work. I used to love going there, hearing stories passed down in Gullah, a slave language which is almost hypnotic to listen to. I've been away for years, but I'm sure there must be some quilt shops around there.
There were spice blenders, too, that would come up with interesting names for their spicy blends, like "burns the hair off your butt, but real tasty". I also remember fondly a disabled man who would make the most beautiful boxes and such out of driftwood.
And if you love huge old trees, the Angel Oak is on John's Island. Hurricane Hugo hurt it some, but it was around before Columbus left Spain. It is supposed to be 1500 years old, with huge branches meandering around, covered in moss, like the ancient soul it is.
http://www.angeloaktree.org/history.htm