My first thought would be to make vertical "stripes". Start with a column of the small blocks in a 1-2-3-4-5 repeat pattern and then add a column of the lighter neutral fabric. For the next small block column, use 2-3-4-5-1, then the neutral, then the blocks in 3-4-5-1-2, then the neutral, etc. If you start and end with the blocks, you can then decide if you want a narrow border of the neutral all the way around. The neutral column can be as narrow or as wide as you feel it needs to be to calm down the visual impact of the blocks. Just an option anyway.