I'm a lefty. Someone told me it's a bit weird for quilting - but I'm learning. I was at JoAnns and complaining about my Fiskar rotary cutter because it kept closing on me when I was trying to use it. Someone at the counter immediately asked me if I was left handed! YES. She told me to get a different cutter, which I did and switched the blade. It works fine.
What gives me a hard time is the Easy Angle ruler! I have to literally turn it upside down so I can measure and cut with my left hand. I always have to look at the picture before using this!