Yes. just make sure they've been washed if they're new. They can be tied or quilted with no problems at all. Mom used to take two or three old sheet blankets that were worn out and cut the best pieces out of one or two to lay over the holes in the first one then lay the quilt top on and quilt them. There was never a problem but she wasn't trying to win awards, just keep us kids warm in a drafty old farm house.