I've done pin basting (not bad), used a basting gun (the first one, which I lost, worked well; recently bought another one and it broke almost immediately; and I often use basting spray. Basting spray is probably my favorite. Don't overspray and you should be okay.
I haven't done any queen-size quilts, large lap quilts are about as big as I make, so can't offer any opinions on how large pieces are most easily basted.