I have used poly/cotton blends 50/50 and I hand quilted with no problem. I also have a poly cotton machine quilted bed cover with polyester batting,(shop bought)which is 20 years old, although well worn as you can well imagine, (it is now used as a dog blanket) it has stood up well to the test of time! I used Poly thread for poly fabrics and cotton thread for cotton fabrics. Having said all that 100% cotton are my favourites though for hand quilting. I guess what I am saying is when you are learning do try out and experiment with what feels right for you and what your budget can afford.
Gal