My sister took it a few years ago. It worked well for her and she didn't have any major side effects. If I recall correctly, her skin temporarily became dry and a bit reddish, but I think that was to be expected. It resolved itself quickly. She hasn't had problems with acne since then. :)
I do remember that she had to sign a paper saying that she'd been advised to ABSOLUTELY NOT become pregnant, because it could (as in "would" ) cause major problems with the baby. I don't know how or if it would affect males. (?)