My daughter suffered with acne all through her teen years...we tried everything. When she was out of college and still having major problems, the doctor offered the option of Acutane. We knew it was high risk...and high price...but there were no other options for her. She took it for a 6 month period.....went in every month for her prescription, was evaluated by the doctor and had to take a pregnancy test before they would give her the next month prescription.
Long story short....it completely cleared up her acne...as others have said, her only side effects were dry skin. her acne has not resurfaced in almost 10 years. I would recommend it if you have tried all the other options.