I don’t know why not. I have been using them in an appliqué quilt that has some very difficult leaves. I tried every single method and end up using them instead of interfacing. I just place them in the dryer a few times to get the stiffness out of them.
On the other end, I use a new one to hand quilt. After I thread the needle, I make a few stitches through one sheet and the thread goes through the quilt much easier and without ever making knots. I prefer this to the wax.
Lucia