I have done several queen and king size quilts on my domestic machine (a Juki TL98E) and like Delilah I stitch in the ditch to anchor the top and then I use stencils to add depth to the quilt. Don't be afraid of a quilt b/c of it's size. As you work on it, some ideas will come to you on how to stitch it. There are times I don't know what designs I'll use and then i look at
http://quiltingstencils.com and
http://quiltingcreations.com and I get ideas. Good Luck!