I work 50-60 hours a week. I have a DH and four kids but now some are away part of the year at college. I don't get a lot done during the week but sometimes just go into my sewing room and cut a few blocks or something so I am ready when I do have time.
I, like Bottle Blonde, assign all cleaning chores on the weekends to everyone who is living at the house at the time. I have my list but it isn't terribly long. I can spend quite a bit of time sewing on most weekends if I want.
When my kids were little, I got very little sewing done except on vacations. Between my job and their activities and all the other things they needed, it just didn't happen.