I genrally make Art Quilts and the largest of those is 63" X 75". That one I made in 4 sections, thinking it would be too large to fmq in one piece. I ended up sewing the sections together and fmq the whole thing anyway. I am part way thru making a 2 sided (different patterns on each side),king size duvet cover with separate pillow cover, for our comforter. I've thought all along that I will fmq each side to a piece of muslin, to protect the seams from rubbing on the comforter and help prevent fraying in the future. That will probably be stitch -in -the -ditch or a large meander. After the machine quilting is finished, then I'll sew it together to make the duvet. I think the key to fmq w/ a reg. sewing machine, is lots and lots of practice first, before attempting your quilt top. I also found that scrunching the quilt is easier than rolling it into a roll. You aren't fighting that unmanagable roll. A lot might depend on the design you are doing though.