If you can do free motion quilting, here's an idea I got from a LQS staff member. Spray baste (with 505 or something similar) and sandwich just the middle part of your large quilt (top to bottom). That leaves the two outer sides of your quilt top and backing with no batting yet and very easy to still manage the quilt with less bulk. After you finish that middle section, add batting and spray baste one of the sides and do that section allowing you to keep the bulk of what has been completed to the left of your machine, again making it easier to handle. Complete the other side in the same manner. Make sense?