It can be done. It's easier if your machine has a larger throat, but I did once see a king size that was being quilted on a regular machine. I think it's hard on the shoulders. Everyone finds their own system that works. If you start in the center and work out to the corners, you are dealing with a smaller area. I scrunch it up, rather than roll. I find it easier to control. I now have a Viking Sapphire, with a 9" throat. I've done a 60x80 without much problem. Eventually I'll get around to my queen sized quilt. I don't expect to have a problem. I'll just take my time.