That's one reason I hand quilt. I roll the quilt up on two 8' long poles that I encased with batting and muslin. Set it on a table and have it extend out to a rail chair and I'm on my way. Works better than a quilting frame as far as I'm concerned. Just roll it up when you're done for the day if you need the space.
PLUS - I just love, love, love the way hand-quilting looks!