When my daughter lived in NH her apt caught on fire and the firemen told us that any clothes could be treated but if they got wet again the smoke smell would reappear. So, any fabric that has been in a fire is probably ruined. I would just toss it and not live with the possibility of it getting wet again.
As for cat or dog hair you can use one of those sticky rollers or masking tape to lift it off and then put it in the dryer with a with damp hand towel and try to get the remainder of the pet hair off of the quilt. We have two Yorkies who love to lay on the quilts, especially ones my husband quilts for other ladies. Lynne Plotner-Pierce