First, what brand of sewing machine are you trying to use?
Second, put in a fresh needle and bobbin?
Third, check your tension? It might need to be adjusted for the heavier weight of a big quilt.
fourth, are your feed dogs down?
Fifth, check to see if your top thread is winding off in the right direction, check your manual.
I'm sure others will give you more hints. This way I do it.
Good luck!