Yes you can do it on a regular sewing machine. I teach Cotton Theory at the quilt store I work at. To keep organized make sure that you have labels, and label everything. I label and then stack them together, fronts backs, and batting for each. The time consuming part is the cutting. Once that is done it sews together quickly. We teach the placemats or table runner (from her first book) as a beginning project. Once you get the hang of it you can do any of the projects even from her more advanced second book.