I love quilt blocks but I've always been to impatient to do a quilt with lots of blocks. I've just found my new passion. I pick one block I like (usually 4 patch or 5 patch) and use that one block for a huge block, usually about 36" x 36". Then I add borders to hit the 45" x 60" crib quilt size. I am having a ball playing with colors and patterns. I've made two ANNIE'S CHOICE (imagine that!), one WHIRLPOOL, one SISTER'S CHOICE, one TRAILING STAR, and one cheater IRISH CHAIN.
One big advantage to doing one big block is that I can use fabric with bigger designs. You might find a state block, or maybe even a block with your name or your kid's name to use.