Yes. I have. Twice.
If you don't have a frame, it gets VERY unwieldly. I did one oversized "lap" one for my friend's mom last year, and then I did one for my DD's quilt for college. Both have health problems that cause them to be cold. My DD's was an oversized twin. After trying to stuff that through my standard machine, I bought a frame and a new Juki. :lol: