I did some googling. Things are things that I read, I have no experience with any of these. What I learned was:
1. You can hand quilt, but it is heavy and may be much easier to machine quilt
2. It is very heavy
3. Some people use sweaters and make felted wool
4. Fulled wool is really good, but extremely expensive and in limited colors
5. Antique wool quilts often had flannel backing
6. Many people use wool applique's on Flannel fabrics