It takes awhile..i was a good 4 months getting back....i had a total Hysterectomy in 05.....at the 6 month point my hormones where shot....got on premarin....took that about 2 months about killed me.....then found Progesterone cream..and use Real estrogen cream..i feel pretty good.....and My Thyroid is out to, but i take Armour for it...if all the Hormones aren't balanced...a woman or man will feel terrible..trying to get mine alighned...good luck.....Bev