For my 3 year old grandnephew I made a snake quilt (it was all zigzag blocks - half square triangles with the head that was an octogon folded in half -- confusing I know) But the octogon opened (closed using velcro) and so it looked like the snakes were able to open and close their mouths.
Anyhoo, for the eyes I took 2 in circles, stuffed them and drew eyes on with a permanent, non-toxic marker.