I've done some applique by hand and some by machine with invisible thread, but nothing very complicated. I've stuck with pretty simple shapes.
I would like to do the fusible with the machine buttonhole stitch, but wonder if that would hold up to lots of wear & tear if used for kids' quilts.
I'd also like to do needle turn, but haven't tried it yet.
I enjoy handwork-find it relaxing. But by machine gets completed faster.