If you use muslin squares as a base for crazy quilting, they should be fine. The very lightweight fabrics I would apply iron-on interfacing to before cutting, just to add durability. If you plan on washing the quilt, wash fabrics first to prevent uneven shrinkage. I use mesh lingerie bags if I think anything will unravel too much - learned the hard way on that.
With all the beautiful shiny threads out now, it could be stunning. Be sure to post a picture so we can oooh and ah!