You can change the size of the block by simply changing the size of the HST. There are 4 HST's across each Depression Block. A queen quilt is usually about 86 x 93. Decide how many blocks across you want and that will determine the size of the block. Then each HST will have to be 1/4 th of each block + 1/2 inch for seam allowance.
Hope this helps some.