I quilt on my regular sewing machine. I can do queen sized quilts on it - yes, it's a lot of shoving and maneuvering, but it's not THAT hard! I prefer to just do freemotion stippling all over it, since that's the fastest way to finish it. Unless I wanted to go into business doing professional machine quilting for others, I could not justify the expense of a quilting machine.
I also quilt by hand, but not often. I save it for special things. Everything else, from table runners to bed quilts, gets stippled.