Absolutely, I have three long under the bed boxes filled with cut up mens/womens shirts that I've gotten at the thrift stores. I'm in the process of making 3 quilts from 9 patches and hearts for my brothers. I've got my eye on the pretty pastels for a girly quilt. Have you visited quiltville.com? Bonnie Hunter is all about reusing shirts and scraps. She has dozens of free quilt patterns, as well as 2 books out with another book due out this winter.