Yes I have made several large quilts that I use on my bed which is queen sized. And I did quilt a few on my domestic machine before I got my first short arm and then advance to a Gammell Premier which is a mid arm. I don't do a lot for others other than family, but I have several that I need to do for myself. I use an 80/20 cotton/poly blend or all cotton so they are not too hot to have on the bed year round here in KS. That is part of the beauty of cotton, comfort besides being user friendly, poly has a mind of it's own. I like the idea of having made quilts that I and my family can use rather than saving them for strangers to use after I'm gone.