Same here - I have a 3x rule. If I take it out twice and on the third try (even with new pieces) it is still off - it stays off.
I found out over time that those "glaring errors" when we see the piece close to our nose WILL disappear once the top is put together and the quilt is quilted. Used to insist that the "glaring error" would just jump up and bite me every time I look at the quilt - and then I literally couldn't even find it later. So I don't stress any longer. I still have my 3x rule though.