I love fusible batting and I use it for everything that I plan to machine quilt. I'd love to hear from someone who hand quilts, because I'd like to know if there's a problem.
I've never had a problem ironing it on my regular ironing board no matter how big the project. Just iron the amount that fits and move on, same as with a piece of fabric only you're ironing 3 layers.
Once it's quilted and goes through the wash it's just a lovely soft batting in cotton, polyester or cotton/poly blend. Actually the application process used for fusible batting uses less product than a home quilter would use using a spray and you don't have to worry about inhaling fusible batting.
I did some research on fusible batting and basting spray and based on the results I'll be sticking with fusible batting and staying well clear of most basting sprays.
Here's the thread if anyone is interested:
http://www.quiltingboard.com/t-61846-1.htm