Absoluely. I do many quilts, all sizes, that I piece together. You can use left over fabric and make a pattern, or just strips of material. If you hand quilt, the more seams you have it might be a little more difficult. If you machine quilt or send it out, that's not a problem. I did a quilt for 2 granddaughters, and the quilt was actually reversible. And of course the girls liked the back side best.