Be experimental and creative. There are no quilt police. I have seen many a different quilt made from some of the strangest fabrics other than 100% cotton. Give it a try, and you may learn some things about why we use 100% cotton...tee hee and then again...you may learn some lessons that that others need to hear. Worse that can happen? You might have a lovely quilt to give to someone that does not care if you used differnt fabrics!