i have a number of quilts that contain both hand and machine quilting, they are beautiful, and i see no reason to not do it that way if that is what you want. i had one that i hand quilted around all of my hand embroidery in the center of the quilt but the borders are machine quilted. i have one that was hand embroidered (as the quilting) then finished with the machine. lots of the (big- award winning- internationally known quilters) all use both techniques in their quilts. go for it