I've done 2 quilts on my serger. I purchased a pattern call "Scrappy Serger Quilt". There are other patterns available. Basically you cut strips from several different colors, serge them to make rows, from the rows you cut blocks, lay your blocks out in a pattern, then serge them into rows. Then you join a row, batting, backing. After you have 2 rows joined you can quilt it as you go, then join the 3rd row, quilt, join 4th, etc. I used polyester batting & didn't notice any problem with seams. I did find it easier to pin & serge a short distance, remove pin, serge. Just be careful not to sew over a pin with your serger, as you can damage the knife.