I am working on a normal pieced cotton quilt top and backing it with flannel right now!!! I do not use Warm and Natural batting but I do pin as normal. Set your stitch lengh a bit longer and use a walking foot if you are doing stitch in the ditch which is what I would reccommend when using fleece. I have done some free motion stuff but it just doesn't feel the same....looked OK tho.
jodi in leavenworth
be sure to practice on a few scraps to get your stitch length set first!!