This "hole in the quilt" happened to me as well. While all quilts are special, this one was very dear to my heart and the person I was giving it to as I was retiring and moving quite a distance away. It was dead center on the back side and about the size of a quarter. I took a small piece of fabric that I used in the quilt (contrasting to hole) and cut out a heart. I appliqued it over the hole and attached a note saying, "I have taken a little piece of this quilt out and replaced it with a piece of my heart for you to always be reminded how much I love you." It turned out to be more meaningful than I ever imagined.