if flannel you can pratically make any block....regualar cotton as well but if a stretchy cotten like t shirt material..I prefer to bond it with another fabric so when you cut it apart it has substance and doesnt stretch in every direction. I cut the clothing apart and decide a pattern from the amount of fabric I have to work with ..Usually with most memory quilts you have to add some accompanying fabric to make a design or to make it big enough...which only enhances the quilt but its still a memory quilt...you can add embellishments or photos too